Presentation Details
| Effect of Acute Deep Vein Thrombosis in Patients with lung cancer in Acute Deep Vein Thrombosis (DVT): A study of the Nation Inpatient Sample Maria Cristina Cuartas- Mesa, Nana Yaa Ampaw, Edwin Gwira- Tamattey, Enrique Martinez- Trevino, Alejandro Nieto- Dominguez , Ekrem Turk . John H.Stroger, Jr.Hospital of Cook County, Chicago, IL, USA |
Abstract
BACKGROUND: Lung cancer, like most cancers, is a high-risk condition for developing deep vein thrombosis; however, little is known about the effects of deep vein thrombosis on the outcomes of patients with lung cancer. OBJECTIVES To identify the possible effects associated with the development of deep vein thrombosis in patients with lung cancer. METHODS The National Inpatient Sample database was utilized to obtain pertinent data. Using ICD-10 codes, total hospitalizations with lung cancer were extracted from the 2016 to 2020 database out of which adult patients with a secondary diagnosis of Acute DVT were determined. Statistical analysis was performed on STATA, using multivariable logistic regression to compare the odds of all-cause mortality, the length of stay, total hospital charges, and various comorbidities in lung cancer patients with acute DVT to those without. RESULTS Most patients were male (50.4%) and White (72.7%), followed by black (14.8%) and other races (7.4%) patients. The mean age was 68.6 years; most of the population was elderly (65.2%). There was a statistically significant increase in the proportion of patients with a Charlson score > 3 (p <0.01), which reflects an overall rise in the comorbidity burden in the study population. In hospitals, mortality accounted for 1.6% of admissions; when adjusted for age and gender, outcomes did not differ significantly between sex and income quartiles. Interestingly, there was a statistically significant increase in the rate of comorbidities such as myocardial infarction (MI) OR of 2 p <0.001, CVA with OR 1.66 p <0.001, intracranial bleeding with OR 2.2 p <0.001, intubation OR 1.3 p <0.001, AKI 1.3 p <0.001, PE OR 16 p <0.001, Red blood cell transfusion OR 1.49 p <0.001 and cardiogenic shock with OR 1.6 p=0.021. This was opposed to a reduced rate of requirements of Hemodialysis with OR 0.35 p <0.001 and respiratory complications with OR 0.77 p= 0.021. CONCLUSIONS Lung cancer carries significant morbimortality in patients, and deep vein thrombosis seems to be associated with a higher burden of comorbidities in this population, as mentioned above. Further research is needed to understand this pathophysiology further to prevent episodes and improve patients' quality of life.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.