Presentation Details
| Multispecies analysis of the ERAD pathway in platelet function Anna Dahlgren. |
Abstract
Atypical Equine Thrombasthenia (AET) is a heritable platelet disorder found in horses due to aberrant platelet signaling after thrombin stimulation, preventing platelets from fully activating or efficiently binding to fibrinogen, leading to prolonged bleeding. Despite the negative effects on horse health and racing performance, the underlying etiology of this disorder is unknown. The utilization of horse, zebrafish, mouse, and human cell culture models to identify the endoplasmic reticulum - associated protein degradation (ERAD) gene involved in the mechanism of AET will be discussed.
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